Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation
US6696454B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 12, 2001 |
| Grant date | Feb 24, 2004 |
| Priority date | — |
| Expiry date | Dec 12, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/91171
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides a method for the treatment of a subject in need of treatment for osteoarthritis comprising administering to said subject an amount of an inhibitor of spermidine biosynthesis sufficient to effect a substantial inhibition of spermidine biosynthesis. This invention also provides the use of an inhibitor of spermidine biosynthesis in the treatment of a subject in need of treatment of osteoarthritis in an amount sufficient to effect a substantial inhibition of spermidine biosynthesis. This invention further provides a method of preparing a therapeutic composition for the treatment of a subject in need of a treatment for osteoarthritis and the invention further provides a method of identifying an inhibitor of spermidine biosynthesis, whereby the inhibitor is a spermidine synthase inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.