Anticholinergics, processes for the preparation thereof, and pharmaceutical compositions

US6696462B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Christian Eickmeier · Mittelbiberach, DE
• Sabine Germeyer · Biberach an der Riß, DE
• Matthias Grauert · Ingelheim am Rhein, DE
• Sabine Pestel · Biberach, DE
• Michael Pieper · Ingelheim am Rhein, DE
• Georg Speck · Ingelheim am Rhein, DE
• Steffen Breitfelder · Aßmannshardt, DE

Key dates

• Filing date: Jan 16, 2003
• Grant date: Feb 24, 2004
• Expiry date: Jan 16, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D451/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of formula 1 wherein:X- is an anion with a single negative charge;A and B, which are identical or different, are each —O—, —S—, —NH—, —CH2—, —CH═CH—, or —N(C1-C4-alkyl)—;R is hydrogen, hydroxy, —C1-C4-alkyl, —C1-C4-alkyloxy, —C1-C4-alkylene-halogen, —0—C1-C4-alkylene-halogen, —C1-C4-alkylene-OH, —CF3, —CHF2, —C1-C4-alkylene-C1-C4-alkyloxy, —0—COC1-C4-alkyl, —0—COC1-C4-alkylene-halogen, —C1-C4-alkylene-C3-C6-cycloalkyl, —0—COCF3, or halogen;R1 and R2, which are identical or different, are each —C1-C5-alkyl, which is optionally substituted by —C3-C6-cycloalkyl, hydroxy, or halogen, orR1 and R2 together are a —C3-C5-alkylene bridge;R3, R4, R3′, and R4′, which are identical or different, are each hydrogen, C1-C4-alkyl, C1-C4-alkyloxy, hydroxy, —CF3, —CHF2, —CN, —NO2, or halogen;RX and RX′, which are identical or different, are each hydrogen, C1-C4-alkyl, C1-C4-alkyloxy, hydroxy, —CF3, —CHF2, —CN, —NO2, or halogen, orRX and…