Cyclobutenedione compounds
US6696469B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 12, 2001 |
| Grant date | Feb 24, 2004 |
| Priority date | — |
| Expiry date | Oct 12, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula (I): wherein:X represents a heterocycle bonded to the remainder of the molecule by a nitrogen atom of the heterocycle, or an —NR2R3 group wherein R2 represents hydrogen or alkyl, and R3 represents aryl, 1,3 dihydro-2H-benzimidazolyl-2-one or alkyl substituted by a heterocycle,n represents zero or 1,R1 represents hydrogen or alkyl,Ra represents a single bond or an alkylene chain,A represents nitrogen or CH,E represents nitrogen or CRe, wherein Re is as defined in the description,Rb represents a single bond or an alkylene chain as defined in the description,W represents aryl or heteroaryl,Their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid, andmedicinal products containing the same which are useful for treatment of diseases or pathological conditions in which endothelial dysfunction is known.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.