Process for the production of 6,7-diols of steroidal compounds
US6696580B2 · kind B2 · utility
4Cited by
1References
14Claims
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Key dates
| Filing date | May 22, 2002 |
| Grant date | Feb 24, 2004 |
| Priority date | — |
| Expiry date | May 22, 2022 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding &agr;,&bgr;-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the &agr;,&bgr;-unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.