Alzheimer's disease secretase, APP substrates therefor, and uses therefor
US6699671B1 · kind B1 · utility
20Cited by
22References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 13, 1999 |
| Grant date | Mar 2, 2004 |
| Priority date | — |
| Expiry date | Oct 13, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96472
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.