Catalytic reduction of alkyne compounds

US6699911B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Johannes Grimmer · Aarhus, DK
• Thomas Müller · Biberach, DE
• Hansgeorg Ernst · Speyer, DE

Key dates

• Filing date: Sep 18, 2001
• Grant date: Mar 2, 2004
• Expiry date: Dec 5, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process is provided for the preparation of cyclohexene derivatives of general formula I or II: in which the substituents R1 and R2 independently of one another are defined as follows:R1 is R2 is OH or a protective group convertible to a hydroxyl group by hydrolysis;R3 and R4 are hydrogen or C1-C4-alkyl; andR5 is hydrogen or C1-C4-acyl,by the reduction of alkyne compounds of general formula III or IV: in which the substituents R1 and X are as defined above, wherein the reducing agent used is a mixture of zinc and at least one compound B selected from the group consisting of ammonium salts, copper salts and alkali metal and alkaline earth metal salts.