Assays for the detection of microtubule depolymerization inhibitors
US6699969B1 · kind B1 · utility
2Cited by
22References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 28, 2000 |
| Grant date | Mar 2, 2004 |
| Priority date | — |
| Expiry date | Jul 23, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/68
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention provides assays for agents that modulate (e.g. upregulate, downregulate or completely inhibit) microtubule depolymerizing or microtubule severing proteins. Such agents will have profound effects on progression of the cell cycle and act as potent anti-mitotic agents. The microtubule severing protein or microtubule depolymerizing protein is preferably a katanin, a p60 subunit of a katanin, an XKCM 1, or an OP18 polypeptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.