Reshaped human anti-HM 1.24 antibody
US6699974B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 1, 1999 |
| Grant date | Mar 2, 2004 |
| Priority date | — |
| Expiry date | Apr 1, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A reshaped human anti-HM 1.24 antibody comprising:(A) an L chain comprising(1) the C region of a human L chain, and(2) the V region of an L chain comprising the FR of a human L chain and the CDR of the L chain of a mouse anti-HM 1.24 monoclonal antibody; and(B) an H chain comprising(1) the C region of a human H chain, and(2) the V region of an H chain comprising the FR of a human H chain and the CDR of the H chain of a mouse anti-HM 1.24 monoclonal antibody.Since most of this reshaped human antibody is derived from human antibody and the CDR has a low antigenicity, the reshaped human antibody of the present invention has a low antigenicity and, therefore, is expected to be-used for medical treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.