Prodrugs activated by targeted catalytic proteins

US6702705B1 · kind B1 · utility

Assignee

• IGEN International, Inc. · US

Inventors

• Reid W. von Borstel · Potomac, US
• Jan Casadei · Bethesda, US
• Balreddy Kamireddy · Rockville, US
• John Kenten · Gaithersburg, US
• Mark Martin · Bethesda, US
• Richard J. Massey · Rockville, US
• Andrew Napper · Salem, US
• David M. Simpson · Murfreesboro, US
• Rodger Smith · Jefferson, US
• Richard C. Titmas · Rockville, US
• Richard O. Williams · Potomac, US

Key dates

• Filing date: Feb 22, 1995
• Grant date: Mar 9, 2004
• Expiry date: May 4, 2019

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.