Antibody conjugate methods for selectively inhibiting VEGF
US6703020B1 · kind B1 · utility
88Cited by
54References
49Claims
0Family size
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Key dates
| Filing date | Apr 28, 2000 |
| Grant date | Mar 9, 2004 |
| Priority date | — |
| Expiry date | Apr 28, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present invention thus provides new antibody-based compositions, methods and combined protocols for treating cancer and other angiogenic diseases. Advantageous immunoconjugate and prodrug compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.