Injectable bone substitute material containing non-ceramic hydroxyapatite cement

US6703038B1 · kind B1 · utility

Assignee

• UNIVERSITAETSKLINIKUM FREIBURG · DE

Inventors

• Dirk Schaefer · Hamburg, DE
• Thomas Kiefer · Berlin, DE
• Gerhard Stark · Althengstett, DE
• Ulrich Kneser · Glückstadt, DE

Key dates

• Filing date: Nov 22, 2000
• Grant date: Mar 9, 2004
• Expiry date: May 15, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/02
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A bone substitute material is prepared which comprises a soft matrix, living cells and a setting matrix comprising non-ceramic hydroxyapatite cement. The bone substitute material can be injected minimally invasively into a bone defect with a suitable injection apparatus. In an embodiment, living cells are mixed with a fibrinogen solution and then with a thrombin solution to form the soft matrix, and the soft matrix is mixed with an aqueous solution of non-ceramic hydroxyapatite cement to obtain the bone substitute material which remains unsolidified until after application to a body.