Evaluating and predicting clinical outcomes by gene expression analysis

US6703202B2 · kind B2 · utility

Assignee

• OXO CHEMIE AG · DE

Inventors

• Michael S. McGrath · Burlingame, US
• Stefan Meuer · Worms, DE
• Friedrich-Wilhelm Kuehne · Munich, DE

Key dates

• Filing date: Nov 30, 2000
• Grant date: Mar 9, 2004
• Expiry date: Nov 30, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Methods of determining clinical outcomes in patients suffering from a pathological condition or syndrome are provided. Levels of intracellular gene expression re measured from a clinical sample provided by the patient, and the levels are compared to reference levels. Deviations from reference levels are predictive of clinical outcomes, for example, disease progression or response to therapeutic intervention.