Methods for expanding antigen-specific T cells
US6703238B2 · kind B2 · utility
41Cited by
30References
19Claims
0Family size
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Key dates
| Filing date | Mar 20, 2001 |
| Grant date | Mar 9, 2004 |
| Priority date | — |
| Expiry date | Mar 20, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/70
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for expanding antigen-specific T cells in vitro are provided. The methods involve contacting hematopoietic precursor or progenitor cells with a heteroconjugate containing an inhibitor of dipeptidyl peptidase (DPIV) attached to an antigenic peptide, optionally with a culture step to expand T cells with a DPIV inhibitor. The culture may be performed in the absence of exogenously provided cytokines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.