Methods for delivery therapeutic compounds across the blood-brain barrier
US6703381B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 14, 1998 |
| Grant date | Mar 9, 2004 |
| Priority date | — |
| Expiry date | Aug 14, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugates comprise a therapeutic compound conjugated to an oligomer, wherein the oligomer comprises a lipophilic moiety coupled to a hydrophilic moiety. The conjugates of the invention further comprise therapeutic agents such as proteins, peptides, nucleosides, nucleotides, antiviral agents, antineoplastic agents, antibiotics, etc., and prodrugs, precursors, derivatives and intermediates thereof, chemically coupled to amphiphilic oligomers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.