Small molecule inhibitors targeted at Bcl-2
US6703382B2 · kind B2 · utility
66Cited by
1References
8Claims
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Key dates
| Filing date | Aug 16, 2001 |
| Grant date | Mar 9, 2004 |
| Priority date | — |
| Expiry date | Aug 16, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for promotion of cell death in tumor cells using tricylo-dibenzo-diazocine-dioxides that bind to a pocket of Bcl-2 and block the Bcl-2 anti-apoptotic function. A method of use of a compound of the general structural Formula (I) for use in treatment of cancer: wherein X and Y, and R and R1, and R2, R3, R4 and R5, and A and A1, have any of the values defined in the specification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.