Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US6703396B1 · kind B1 · utility
49Cited by
21References
28Claims
0Family size
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Key dates
| Filing date | Mar 13, 1995 |
| Grant date | Mar 9, 2004 |
| Priority date | — |
| Expiry date | Dec 13, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers. The nucleoside enantiomer (−)-2-hydroxymethyl-5-(5-flurocytosin-1-yl)-1,3-oxathiolane is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.