Substituted 4-phenyltetrahydroisoquinolinium salts, process for their preparation, their use as a medicament, and medicament containing them

US6703405B2 · kind B2 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Armin Hofmeister · Frankfurt, DE
• Hans-Jochen Lang · Hofheim, DE
• Uwe Heinelt · Wiesbaden, DE
• Markus Bleich · Brechen, DE
• Klaus Wirth · Frankfurt am Main, DE

Key dates

• Filing date: Dec 20, 2002
• Grant date: Mar 9, 2004
• Expiry date: Dec 20, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel compounds of the formula I in which R1 to R10 R7 are as defined herein. In one embodiment, these compounds may be used as antihypertensives, for reducing or preventing ischemia-induced damage, as medicaments for surgical intervention for the treatment of ischemias of the nervous system, of stroke and of cerebral edema, of shock, of impaired respiratory drive, for the treatment of snoring, as laxative, as agent against ectoparasites, to prevent the formation of gallstones, as antiatherosclerotics, agents against late complications of diabetes, cancers, fibrotic disorders, endothelial dysfunction, organ hypertrophies and hyperplasias. In another embodiment, the compounds may be inhibitors of the cellular sodium-proton antiporter and influence serum lipoproteins and thus be used for the treatment of atherosclerotic lesions.