Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them

US6703411B2 · kind B2 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Andreas Weichert · Egelsbach, DE
• Udo Albus · Florstadt, DE
• Hans-Willi Jansen · Niedernhausen, DE
• Heinz-Werner Kleemann · Bischofsheim, DE
• Hans-Jochen Lang · Hofheim, DE

Key dates

• Filing date: Jan 17, 2001
• Grant date: Mar 9, 2004
• Expiry date: Jan 17, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Benzoylguanidines of the formula (I) in which R1 to R4 have the meanings given in the specification and claims are suitable as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and infarct treatment and for the treatment of angina pectoris. The compounds of the invention also preventively inhibit the pathophysiological processes in the formation of ischemically induced damage, in particular in the triggering of ischemically induced cardiac arrhythmias.