Brain and heart cyclic nucleotide gated ion channel compounds and uses thereof

US6703485B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Eric R. Kandel · Yonkers, US
• Bina Santoro · Roma, IT
• Dusan Bartsch · Heidelberg, DE
• Steven Siegelbaum · New York, US
• Gareth R. Tibbs · New York, US
• Seth Grant · Edinburgh, GB

Key dates

• Filing date: May 28, 1998
• Grant date: Mar 9, 2004
• Expiry date: May 28, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides an isolated nucleic acid encoding a BCNG protein or a portion thereof or BCNG-related protein or a portion thereof. The present invention further provides a method for identifying a nucleic acid in a sample which encodes a BCNG protein or a BCNG-related protein. The present invention also provides a method for testing whether a compound affects the expression of a BCNG protein or a BCNG-related protein. In addition, the present invention further provides a method for identifying a compound capable of interacting with a BCNG protein or a BCNG-related protein. Also, the present invention provides a method for identifing a compound capable of modulating BCNG protein or BCNG-related protein activity. Further, the present invention also provides a method of treating a condition in a subject which comprises administering to the subject an amount of the provided compound, effective to treat the condition.