Method for producing 5-aryl nicotinaldehydes

US6703509B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Andreas Bathe · Darmstadt, DE
• Heinz-Hermann Bokel · Darmstadt, DE
• Thomas Keil · Marl, DE
• Ralf Knieriemen · Groß-Zimmern, DE
• Christoph Murmann · Reinheim, DE

Key dates

• Filing date: Aug 6, 2002
• Grant date: Mar 9, 2004
• Expiry date: Aug 6, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/80
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that the molar ratio between palladium and ligand is from 1:5 to 1:15 in the case of monodentate ligands and from 1:2.5 to 1:7.5 in the case of bidentate ligands.