N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate

US6706721B1 · kind B1 · utility

Assignee

• OSI Pharmaceuticals, LLC · US

Inventors

• Douglas J. M. Allen · Indianapolis, US
• Timothy Norris · Gales Ferry, US
• Jeffrey W. Raggon · Uncasville, US
• Dinos P. Santafianos · Manchester, US
• Ravi M. Shanker · Groton, US

Key dates

• Filing date: Jul 29, 1999
• Grant date: Mar 16, 2004
• Expiry date: Jul 29, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/94
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to the anhydrous and hydrate forms of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate. The invention also relates to pharmaceutical compositions containing N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate and to methods of treating hyperproliferative disorders, such as cancer, by administering N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate.