Backbone-cyclized BPI peptidomimetics
US6706862B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 20, 2000 |
| Grant date | Mar 16, 2004 |
| Priority date | — |
| Expiry date | Apr 20, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel backbone-cyclized BPI peptide analogs and methods of making the same by the use of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units used in the synthesis of these backbone-cyclized peptide analogs are N&agr;-functionalized amino acids constructed to include a spacer and a terminal functional group. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. A plurality of these N&agr;&ohgr;-functionalized amino acids are incorporated into a library of peptide sequences, preferably during solid phase peptide synthesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.