Methods for separating a tocopherol from a tocopherol-containing mixture
US6706898B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jul 27, 1999 |
| Grant date | Mar 16, 2004 |
| Priority date | — |
| Expiry date | Jul 27, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/72
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to method for separating tocopherol from a first tocopherol admixture by heating the first tocopherol admixture composed of at least one tocopherol, a fatty acid, and an esterifying compound to esterify the fatty acid to produce a second tocopherol admixture composed of the tocopherol, the esterified fatty acid, and the unesterified fatty acid; distilling the second tocopherol admixture with the esterified fatty acid to remove the unesterified fatty acid from the second tocopherol admixture to produce a third tocopherol admixture composed of the tocopherol, with substantially removed unesterified fatty acid; distilling the third tocopherol admixture for a sufficient time and temperature to substantially remove the tocopherol from the third tocopherol admixture to produce a fourth tocopherol admixture composed of the removed tocopherol and a non-tocol component; and extracting the tocopherol from the fourth tocopherol admixture with an extraction solvent composed of a polar, organic solvent that is miscible with water to produce a two phase system composed of a first phase containing the majority of the extraction solvent and the second phase, wherein the selec…
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