Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
US6709858B1 · kind B1 · utility
1Cited by
8References
14Claims
0Family size
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Key dates
| Filing date | Nov 3, 1998 |
| Grant date | Mar 23, 2004 |
| Priority date | — |
| Expiry date | Nov 3, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene of interest in mammalian host cells are provided, as well as methods therefor. Inducible expression of the transgenes at high levels under physiologic conditions results from induction by hyperthermic conditions relative to the basal temperature of the host cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.