Pyrrolo[2,1-B][3,1] benzothiazepines and their use for the preparation of medicaments with antipsychotic activity

US6710041B2 · kind B2 · utility

Assignee

• SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. · IT

Inventors

• Patrizia Minetti · Pomezia, IT
• Assunta Di Cesare · Roma, IT
• Domenico Mastroianni · Pomigliano d'Arco, IT
• Giuseppe Campiani · Siena, IT
• Vito Nacci · Siena, IT

Key dates

• Filing date: Feb 3, 2003
• Grant date: Mar 23, 2004
• Expiry date: Feb 3, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula (I): where: R=H, Cl, Br, F, I, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkyl, or C5-C6 cycloalkyl; R1 =C1-C4 dialkylamine, where the alkyl groups are the same or different from one another, 4-alkyl-1-piperazinyl, 4-hydroxyalkyl-1-piperazinyl, 1-imidazolyl, 4-alkyl-1-piperidinyl, or 4-alkyl-1-homopiperazinyl; R2 =H, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkyl, CHO, or CH=NOH; R3 =H, CHO; or the pharmaceutically acceptable salts thereof.