5-Substituted-3(2H)-furanones useful for inhibition of farnesyl-protein transferase
US6710078B2 · kind B2 · utility
2Cited by
13References
38Claims
0Family size
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Key dates
| Filing date | Aug 23, 2002 |
| Grant date | Mar 23, 2004 |
| Priority date | — |
| Expiry date | Aug 23, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of Formula (I): wherein R1, R2, R3, X, Y, Z and Q are as defined in the specification which compounds are inhibitors of Ras farnesyl-protein transferase enzyme (FPTase), and useful in treating ras oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid and processes for the preparation of said compounds of Formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.