Compositions, apparatus and methods for facilitating surgical procedures
US6711436B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 27, 1999 |
| Grant date | Mar 23, 2004 |
| Priority date | — |
| Expiry date | Sep 27, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2210/125
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are provided for conducting diagnostic or therapeutic medical or surgical procedures in a patient wherein, during the procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an atrioventricular (AV) node blocker. In one embodiment, compositions including an AV node blocker and a &bgr;-blocker are provided, wherein the &bgr;-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of techniques, including minimally invasive microsurgical techniques. Methods for performing a diagnostic or therapeutic procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. In one embodiment, the heart …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.