Pharmaceutical aerosol composition containing HFA 227 and HFA 134a
US6713047B1 · kind B1 · utility
11Cited by
1References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 18, 2001 |
| Grant date | Mar 30, 2004 |
| Priority date | — |
| Expiry date | Jul 18, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P11/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In a solution composition for use in an aerosol inhaler which comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility compound the use of a mixture of HFA 134a and HFA 227 allows to modulate the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler to target specific regions of the respiratory tract. Moreover the fine particle dose (FPD) of the active ingredient in the composition increases by reducing the metering chamber volume.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.