Modulation of A&bgr; levels by &bgr;-secretase BACE2
US6713276B2 · kind B2 · utility
43Cited by
2References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 20, 2001 |
| Grant date | Mar 30, 2004 |
| Priority date | — |
| Expiry date | Aug 26, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is based on the findings that BACE 2, a homolog of &bgr;-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of A&bgr;. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE 2 to suppress A&bgr; production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.