Patent · US Expired

Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

US6713452B2 · kind B2 · utility

11Cited by

167References

104Claims

0Family size

Assignee

Nobex Corporation · US

Inventors

Nnochiri Ekwuribe · Cary, US
Christopher H. Price · Chapel Hill, US
Aslam M. Ansari · Rockville, US
Amy L. Odenbaugh · Morrisville, US

Key dates

Filing date	Jun 4, 2001
Grant date	Mar 30, 2004
Priority date	—
Expiry date	Dec 22, 2021

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P19/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. Moreover, the mixture may be more effective at surviving an in vitro model of intestinal digestion than non-conjugated calcitonin. Furthermore, the mixture may exhibit a higher bioavailability than non-conjugated calcitonin.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.