Organoboron derivatives and process for coupling organic compounds
US6713566B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 6, 2001 |
| Grant date | Mar 30, 2004 |
| Priority date | — |
| Expiry date | Aug 6, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F5/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a process for covalently coupling organic compounds which comprises: reacting an olefinic compound having at least one carbon to carbon double bond or an acetylenic compound having at least one carbon to carbon triple bond with a diboron derivative in the presence of a Group 8-11 metal catalyst to form an organoboron intermediate having an organoboronate residue on at least one carbon atom of the respective double or triple bond; and reacting the organoboron intermediate with an organic compound having a halogen or halogen-like substituent at a coupling position in the presence of a Group 8-11 metal catalyst and a suitable base, whereby the olefinic or acetylenic compound is coupled to the organic compound via a direct bond between the carbon atom having the organoboronate residue and the coupling posiitijno. This invention also relates to a process for preparing an organoboron derivative which comprises reacting an olefinic compound having a leaving group in at the allylic position with a diboron derivative in the presence of a Group 8-11 metal catalyst such that the leaving gruop is replaced with an organoboronate residue. The invention further relates t…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.