Human antibodies derived from immunized xenomice

US6713610B1 · kind B1 · utility

Inventors

• Raju Kucherlapati · Darien, US
• Aya Jakobovits · Beverly Hills, US
• Daniel G. Brenner · San Mateo, US
• Daniel J. Capon · Hillsborough, US
• Sue Klapholz · Stanford, US

Key dates

• Filing date: Jul 11, 2000
• Grant date: Mar 30, 2004
• Expiry date: Sep 1, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2840/203
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.