Process for producing erythromycin derivative
US6713615B2 · kind B2 · utility
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Key dates
| Filing date | Feb 12, 2003 |
| Grant date | Mar 30, 2004 |
| Priority date | — |
| Expiry date | Feb 12, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is provided a preparation process useful for an efficient synthesis of 6-O-substituted ketolide derivatives by combining a characterized step of introduction of a substituent at the 6-position by selective cleavage of a C—O bond of the cyclic acetal at the 9-position side via 6,9-cyclic acetal 5-O-desosaminyl erythronolide derivative, a step of conversion into carbonyl groups at the 9- and 3-positions, and a step of 11,12-cyclic carbamation to lead to 6-O-substituted ketolide derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.