Pneumolysin mutants and pneumococcal vaccines made therefrom
US6716432B1 · kind B1 · utility
11Cited by
0References
21Claims
0Family size
Inventors
Key dates
| Filing date | Jan 25, 1995 |
| Grant date | Apr 6, 2004 |
| Priority date | — |
| Expiry date | Jan 25, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Mutants of pneumolysin that are non-toxic by reason of amino acid substitutions have been constructed. These mutants elicit an immune response in animals that is reactive to wild-type pneumolysin. The invention also encompasses vaccines for humans based on these mutants, including vaccines comprising conjugates with pneumococcal capsular polysaccharides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.