Controlled-release compositions containing opioid agonist and antagonist
US6716449B2 · kind B2 · utility
159Cited by
75References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 8, 2001 |
| Grant date | Apr 6, 2004 |
| Priority date | — |
| Expiry date | Feb 8, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5047
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Controlled-release dosage forms containing an opioid agonist; an opioid antagonist; and a controlled release material release during a dosing interval an analgesic or sub-analgesic amount of the opioid agonist along with an amount of the opioid antagonist effective to attenuate a side effect of the opioid agonist. The dosage form provides analgesia for at least about 8 hours when administered to human patients. In other embodiments, the dose of antagonist released during the dosing interval enhances the analgesic potency of the opioid agonist.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.