Antibodies to interleukin-4 receptors and uses thereof

US6716587B2 · kind B2 · utility

Assignee

• IMMUNEX CORPORATION · US

Inventors

• Bruce Mosley · Seattle, US
• David J. Cosman · Bainbridge Island, US
• Linda S. Park · Seattle, US
• M. Patricia Beckmann · Poulsbo, US
• Carl J. March · Bainbridge Island, US
• Rejean Idzerda · Seattle, US

Key dates

• Filing date: Mar 22, 2002
• Grant date: Apr 6, 2004
• Expiry date: Mar 22, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.