Discordant helix stabilization for prevention of amyloid formation
US6716589B2 · kind B2 · utility
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26Claims
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Assignee
Inventor
Key dates
| Filing date | Nov 19, 2001 |
| Grant date | Apr 6, 2004 |
| Priority date | — |
| Expiry date | Nov 25, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2828
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention is based on the discovery that the presence of a discordant helix in a protein or peptide is predictive of that protein or peptide's ability to form amyloid. The invention includes methods for detecting discordant helices and methods of screening for compounds that stabilize the &agr;-helix of a discordant helix-containing polypeptide. Compounds discovered using these methods are useful for treating or preventing disorders in which amyloid is produced. Such disorders include Alzheimer's disease and prion-associated disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.