Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis

US6716813B2 · kind B2 · utility

Assignee

• House Ear Institute · US

Inventors

• David J. Lim · Pasadena, US
• Haa-Yung Lee · La Cañada Flintridge, US
• Paul J.L. Webster · Pasadena, US
• Ali Andalibi · West Hollywood, US
• Jian Li · Tempe, US
• Tomas Ganz · Los Angeles, US

Key dates

• Filing date: Nov 27, 2001
• Grant date: Apr 6, 2004
• Expiry date: Nov 27, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/47
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein is a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and/or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin and defensins, were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.