Thiochromane derivatives and their use as thrombin inhibitors

US6716834B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Kjell Andersson · Bissenkamp, SE
• Tord Inghardt · Gately Drive, SE
• Olle Karlsson · Mölndal, SE
• Marcel Linschoten · Vega, SE
• Jan-Erik Nystrom
• Gunnel E. Sunden · Göteborg, SE

Key dates

• Filing date: Nov 12, 2002
• Grant date: Apr 6, 2004
• Expiry date: Nov 12, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is provided compounds of formulae I and IA wherein Y, R1, R2, R3, D1 and D2 have meanings given in the description which are useful as, or as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.