Cyclic N-substituted alpha-imino carboxylic acids for selective inhibition of collogenase

US6716853B2 · kind B2 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Petra Stahl · Frankfurt, DE
• Reinhard Kirsch · Braunschweig, DE
• Sven Ruf · Mainz, DE
• Volkmar Wehner · Bischofsheim a.d.Rhön, DE
• Klaus-Ulrich Weithmann · Hofheim, DE

Key dates

• Filing date: Feb 26, 2003
• Grant date: Apr 6, 2004
• Expiry date: Feb 26, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention is related to compounds of formula I to pharmaceutical compositions comprising such compounds, to processes for the preparation of such compounds, and to methods of prevention and treatment of disorders, the progression of which involve an enhanced activity of matrix metalloproteinase 13, by administering to a patient in need thereof, a pharmaceutically effective amount of such compounds.