Antioxidant nitroxides and nitrones as therapeutic agents
US6717012B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 2, 2002 |
| Grant date | Apr 6, 2004 |
| Priority date | — |
| Expiry date | Apr 2, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides novel adamantane compounds having one of the following formulas: wherein:R1 and R3 are H, OH, alkyl, cycloalkyl, amino or aryl, and can be the same or different;R2 is H, NH2, alkyl, OH, COOH, amino, amide, or carbamate;R4-R8 are H, OH, NH2, alkyl, OH, COOH, ester, amino, amide, or alkyloxy, and can be the same or different;R9-R14 are H, alkyl, or phenyl, and can be the same or different;and wherein when any of R1-R8 is amino, the compounds are the free bases and their acid addition salts.The present invention also relates to compositions and methods for treating and/or preventing neurological and inflammatory disorders in a patient by administering a therapeutically effective amount of the compounds of formula (I), (II) or (III) and a pharmaceutically acceptable carrier.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.