Treatment of liver disease and injury with CXC chemokines

US6719969B1 · kind B1 · utility

Assignees

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US
• The University Court of the University of Edinburgh · GB

Inventors

• Cory M. Hogaboam · Ann Arbor, US
• Cynthia L. Bone-Larson · Petersburg, US
• Kenneth J. Simpson · Edinburgh, GB
• Nicholas W. Lukacs · Brighton, US
• Steven L. Kunkel · Ann Arbor, US
• Lisa M. Colletti · Webberville, US
• Robert M. Strieter · Ann Arbor, US

Key dates

• Filing date: Aug 4, 2000
• Grant date: Apr 13, 2004
• Expiry date: Aug 4, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/25
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is the surprising discovery that CXC chemokines function to induce rapid hepatocyte proliferation and liver regeneration after injury. The invention thus provides a range of compositions and methods for use in treating liver injury, including those suitable for treating acetaminophen overdose outside the therapeutic window for N-acetyl-cysteine treatment, and those that limit the hepatotoxic side-effects of gene therapy regimens.