Method of generating cartilage
US6719970B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 10, 2000 |
| Grant date | Apr 13, 2004 |
| Priority date | — |
| Expiry date | Jul 10, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to an improved method for administering live cells to a patient and compositions useful in the method. The composition comprises live cells and biocompatible, biodegradable polymer microparticles. The cells and microparticles of the cell/microparticle composition can be contacted immediately prior to administration, or can be contacted in culture for a specified period of time prior to administration. In the method of the invention, an effective amount of the cell/microparticle composition is administered to a patient in need thereof by injection to a treatment site of the patient to provide a therapeutic effect in the patient. The therapeutic effect can be, for example, the formation of new tissue at the treatment site, or the production and secretion of a biologically active secretory molecule at the treatment site. The composition comprising lives cells and biocompatible, biodegradable polymer microparticles can further comprise a biologically active agent. In a preferred embodiment, the biologically active agent is incorporated into the microparticle. The biologically active agent can be, for example, factors which modulate cell growth.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.