Compounds useful as reversible inhibitors of cysteine proteases

US6720319B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim Pharmaceuticals, Inc. · US

Inventors

• Weimin Liu · Sandy Hook, US
• Denice Spero · West Redding, US
• David Thomson · Ridgefield, US
• Yancey David Ward · Sandy Hook, US
• Erick Richard Roush Young · Danbury, US

Key dates

• Filing date: Oct 1, 2002
• Grant date: Apr 13, 2004
• Expiry date: Oct 1, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.