Nicotine receptor agonists in stem cell and progenitor cell recruitment

US6720340B1 · kind B1 · utility

Assignee

• The Board of Trustees of the Leland Stanford Jr. University · US

Inventors

• John Cooke · Palo Alto, US
• Frances L. Johnson · Iowa City, US
• Anjali Pathak · Campbell, US
• James Jang · San Bruno, US
• Phillip Tsao · Palo Alto, US
• Christopher Heeschen · Frankfurt am Main, DE

Key dates

• Filing date: Jul 28, 2000
• Grant date: Apr 13, 2004
• Expiry date: Jul 28, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia).