Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation

US6720346B2 · kind B2 · utility

Assignee

• Agouron Pharmaceuticals, Inc. · US

Inventors

• Shao Song Chu · Encinitas, US
• Larry Andrew Alegria · Bozeman, US
• Ted M. Bleckman · Village of La Jolla, US
• Wesley Kwan Mung Chong · Encinitas, US
• Rohit Duvadie · San Diego, US
• Lin Li · 安丰镇, CN
• Siegfried H. Reich · San Diego, US
• William H. Romines · San Diego, US
• Michael Brennan Wallace · San Diego, US
• Yi Yang · Belmont, US

Key dates

• Filing date: Jul 5, 2002
• Grant date: Apr 13, 2004
• Expiry date: Sep 18, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.