Methods and compositions for treating intervertebral disc degeneration

US6723335B1 · kind B1 · utility

Inventors

• Jeffrey William Moehlenbruck · Austin, US
• John Ranieri · Austin, US

Key dates

• Filing date: Apr 7, 2000
• Grant date: Apr 20, 2004
• Expiry date: Apr 7, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/38
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A fluid matrix comprising cross-linked remodelable collagen from a donor vertebrate animal is useful for regenerating hydrodynamic function in damaged intervertebral discs in vivo. The matrix may be injectable and may comprise cells and a plurality of purified cell growth factors. The matrix promotes cell growth and elaboration of proteoglycans to facilitate regeneration of native tissues. The collagen in the matrix may be cross-linked using photooxidative catalysis and visible light, and purified cell growth factors are preferably at least partly bone-derived.