Method for producing encased spherical granular grains
US6723372B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 23, 2000 |
| Grant date | Apr 20, 2004 |
| Priority date | — |
| Expiry date | Aug 23, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for the production of encased, spherical granular grains comprising spraying grains which consist of a prostane derivative and a cyclodextrin vehicle, forming together a prostane-cyclodextrine-clathrate, with an aqueous polymer dispersion of ethyl cellulose and/or poly(methyl)acrylic acid ester in a fluidized or boiling bed is disclosed. The polymer dispersion is applied in a thickness equivalent to 1-5% (w/w) of the total mass of the encased grains. The coated grains are cured for at least 24 hours. Grains produced according to this method have a pharmaceutical active ingredient release profile which remains unchanged over the storage time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.