Method for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6723531B2 · kind B2 · utility
56Cited by
25References
25Claims
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Assignee
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Key dates
| Filing date | Mar 16, 1998 |
| Grant date | Apr 20, 2004 |
| Priority date | — |
| Expiry date | Apr 29, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/75
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in a mammalian subject employing modified ecdysone receptors. Also provided are modified ecdysone receptors, as well as homomeric and heterodimeric receptors containing same, nucleic acids encoding invention modified ecdysone receptors, modified ecdysone response elements, gene transfer vectors, recombinant cells, and transgenic animals containing nucleic acids encoding invention modified ecdysone receptor.
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