Indole derivatives

US6723725B1 · kind B1 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Henning Bottcher · Darmstadt, DE
• Joachim Marz · Groß-Gerau, DE
• Hartmut Greiner · Darmstadt, DE
• Jurgen Harting · Darmstadt, DE
• Gerd Bartoszyk · Weiterstadt, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE
• Christoph van Amsterdam · Darmstadt, DE

Key dates

• Filing date: Jan 22, 2002
• Grant date: Apr 20, 2004
• Expiry date: Jan 22, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Indole derivatives of formula I, their salts and solvates, have valuable pharmacological properties together with good tolerability, as they have actions on the central nervous system: wherein R1 and R3 are as defined herein. The compounds have a strong affinity for 5-HT2A receptors, and furthermore exhibit 5HT2A receptor-antagonistic properties. These are therefore suitable both in veterinary and in human medicine for the treatment of functional disorders of the central nervous system and also of inflammation.